csa4_Cul2_ubiquitin_ligase_substrate_complex_cytosol -> Cul2_ubiquitin_ligase_complex
Cul2_ubiquitin_ligase_Orf10_complex -> Cul2_ubiquitin_ligase_complex
Cul2_ubiquitin_ligase_N8_complex -> Cul2_ubiquitin_ligase_complex
CSN5_complex -> Cul2_ubiquitin_ligase_complex
Zyg11B_EloBC_complex -> Cul2_ubiquitin_ligase_complex
Rbx1_Cul2_complex -> Cul2_ubiquitin_ligase_complex
Cul2_ubiquitin_ligase_complex -> Zyg11B_EloBC_complex
ELOB_ELOC_complex -> Zyg11B_EloBC_complex
ZYG11B -> Zyg11B_EloBC_complex
Cul2_ubiquitin_ligase_Orf10_substrate_complex -> Cul2_ubiquitin_ligase_Orf10_complex
Cul2_ubiquitin_ligase_N8_Orf10_complex -> Cul2_ubiquitin_ligase_Orf10_complex
CSN5_complex -> Cul2_ubiquitin_ligase_Orf10_complex
Cul2_ubiquitin_ligase_complex -> Cul2_ubiquitin_ligase_Orf10_complex
Orf10 -> Cul2_ubiquitin_ligase_Orf10_complex
sa105_ubit_traget_cytosol -> csa4_Cul2_ubiquitin_ligase_substrate_complex_cytosol
Cul2_ubiquitin_ligase_complex -> csa4_Cul2_ubiquitin_ligase_substrate_complex_cytosol
Zyg11B_EloBC_complex -> ELOB_ELOC_complex
ELOB_rna -> ELOB_ELOC_complex
ELOB_ELOC_complex -> ELOB_ELOC_complex
ELOC_rna -> ELOB_ELOC_complex
NAE_complex -> NAE_Pevonedistat_complex
Pevonedistat_drug -> NAE_Pevonedistat_complex
Cul2_ubiquitin_ligase_complex -> Rbx1_Cul2_complex
RBX1_rna -> Rbx1_Cul2_complex
Rbx1_Cul2_complex -> Rbx1_Cul2_complex
CUL2_rna -> Rbx1_Cul2_complex
Cul2_ubiquitin_ligase_Orf10_complex -> Cul2_ubiquitin_ligase_Orf10_substrate_complex
sa105_ubit_traget_cytosol -> Cul2_ubiquitin_ligase_Orf10_substrate_complex
Cul2_ubiquitin_ligase_N8_Orf10_E2_Ub_substrate_complex -> Cul2_ubiquitin_ligase_N8_Orf10_E2_substrate_Ub_complex
Cul2_ubiquitin_ligase_N8_E2_substrate_complex -> csa15_Cul2_ubiquitin_ligase_substrate_complex_cytosol
Cul2_ubiquitin_ligase_N8_E2_Ub_substrate_complex -> csa15_Cul2_ubiquitin_ligase_substrate_complex_cytosol
UBE2M_NEDD8_complex -> csa15_Cul2_ubiquitin_ligase_substrate_complex_cytosol
csa4_Cul2_ubiquitin_ligase_substrate_complex_cytosol -> csa15_Cul2_ubiquitin_ligase_substrate_complex_cytosol
Cul2_ubiquitin_ligase_N8_E2_Ub_substrate_complex -> Cul2_ubiquitin_ligase_N8_E2_substrate_Ub_complex
csa15_Cul2_ubiquitin_ligase_substrate_complex_cytosol -> Cul2_ubiquitin_ligase_N8_E2_Ub_substrate_complex
E2_ubiquitinated -> Cul2_ubiquitin_ligase_N8_E2_Ub_substrate_complex
Cul2_ubiquitin_ligase_N8_E2_substrate_Ub_complex -> Cul2_ubiquitin_ligase_N8_substrate_Ub_complex
Cul2_ubiquitin_ligase_N8_substrate_Ub_complex -> Cul2_ubiquitin_ligase_N8_complex
csa15_Cul2_ubiquitin_ligase_substrate_complex_cytosol -> Cul2_ubiquitin_ligase_N8_E2_substrate_complex
E2 -> Cul2_ubiquitin_ligase_N8_E2_substrate_complex
Cul2_ubiquitin_ligase_N8_Orf10_substrate_Ub_complex -> Cul2_ubiquitin_ligase_N8_Orf10_complex
Cul2_ubiquitin_ligase_N8_Orf10_substrate_complex -> Cul2_ubiquitin_ligase_N8_Orf10_E2_Ub_substrate_complex
E2_ubiquitinated -> Cul2_ubiquitin_ligase_N8_Orf10_E2_Ub_substrate_complex
Cul2_ubiquitin_ligase_N8_Orf10_0E2_substrate_complex -> Cul2_ubiquitin_ligase_N8_Orf10_substrate_complex
Cul2_ubiquitin_ligase_N8_Orf10_E2_Ub_substrate_complex -> Cul2_ubiquitin_ligase_N8_Orf10_substrate_complex
Cul2_ubiquitin_ligase_Orf10_substrate_complex -> Cul2_ubiquitin_ligase_N8_Orf10_substrate_complex
UBE2M_NEDD8_complex -> Cul2_ubiquitin_ligase_N8_Orf10_substrate_complex
Cul2_ubiquitin_ligase_N8_Orf10_substrate_complex -> Cul2_ubiquitin_ligase_N8_Orf10_0E2_substrate_complex
E2 -> Cul2_ubiquitin_ligase_N8_Orf10_0E2_substrate_complex
NEDD8 -> UBE2M_NEDD8_complex
NAE_complex -> UBE2M_NEDD8_complex
UBE2M_rna -> UBE2M_NEDD8_complex
UBE2M_NEDD8_complex -> UBE2M_NEDD8_complex
csa4_Cul2_ubiquitin_ligase_substrate_complex_cytosol -> UBE2M_NEDD8_complex
Cul2_ubiquitin_ligase_Orf10_substrate_complex -> UBE2M_NEDD8_complex
NAE_Pevonedistat_complex -> NAE_complex
NAE1_rna -> NAE_complex
NAE_complex -> NAE_complex
UBA3_rna -> NAE_complex
ZYG11B_rna -> ZYG11B
Zyg11B_EloBC_complex -> ZYG11B
E2 -> E1
E1_ubiquitinated -> E1
E1_rna -> E1
E2_rna -> E2
Cul2_ubiquitin_ligase_N8_E2_substrate_Ub_complex -> E2
Cul2_ubiquitin_ligase_N8_E2_substrate_complex -> E2
Cul2_ubiquitin_ligase_N8_Orf10_0E2_substrate_complex -> E2
DUB_rna -> DUB
E1 -> E1_ubiquitinated
Ub_simple_molecule -> E1_ubiquitinated
ATP_simple_molecule -> E1_ubiquitinated
E2 -> E2_ubiquitinated
E1_ubiquitinated -> E2_ubiquitinated
Cul2_ubiquitin_ligase_N8_E2_Ub_substrate_complex -> E2_ubiquitinated
Cul2_ubiquitin_ligase_N8_Orf10_E2_Ub_substrate_complex -> E2_ubiquitinated
E1 -> AMP_simple_molecule
Ub_simple_molecule -> AMP_simple_molecule
ATP_simple_molecule -> AMP_simple_molecule
E1 -> PPi_simple_molecule
Ub_simple_molecule -> PPi_simple_molecule
ATP_simple_molecule -> PPi_simple_molecule
NAE_Pevonedistat_complex -> Pevonedistat_drug
Orf10____ss_sgmRNA_rna -> Orf10
Cul2_ubiquitin_ligase_Orf10_complex -> Orf10
csa4_Cul2_ubiquitin_ligase_substrate_complex_cytosol -> sa105_ubit_traget_cytosol
Cul2_ubiquitin_ligase_Orf10_substrate_complex -> sa105_ubit_traget_cytosol
NEDD8_rna -> NEDD8
Cul2_ubiquitin_ligase_N8_substrate_Ub_complex -> ubit_traget_ubiquitinated
Cul2_ubiquitin_ligase_N8_Orf10_substrate_Ub_complex -> ubit_traget_ubiquitinated
ubit_traget_ubiquitinated -> sa171_ubit_traget_cytosol
DUB -> sa171_ubit_traget_cytosol
$AMP_simple_molecule: ((E1 & Ub_simple_molecule) & ATP_simple_molecule)
$Cul2_ubiquitin_ligase_N8_E2_Ub_substrate_complex: (csa15_Cul2_ubiquitin_ligase_substrate_complex_cytosol & E2_ubiquitinated)
$Cul2_ubiquitin_ligase_N8_E2_substrate_Ub_complex: Cul2_ubiquitin_ligase_N8_E2_Ub_substrate_complex
$Cul2_ubiquitin_ligase_N8_E2_substrate_complex: (csa15_Cul2_ubiquitin_ligase_substrate_complex_cytosol & E2)
$Cul2_ubiquitin_ligase_N8_Orf10_0E2_substrate_complex: (Cul2_ubiquitin_ligase_N8_Orf10_substrate_complex & E2)
$Cul2_ubiquitin_ligase_N8_Orf10_E2_Ub_substrate_complex: (Cul2_ubiquitin_ligase_N8_Orf10_substrate_complex & E2_ubiquitinated)
$Cul2_ubiquitin_ligase_N8_Orf10_E2_substrate_Ub_complex: Cul2_ubiquitin_ligase_N8_Orf10_E2_Ub_substrate_complex
$Cul2_ubiquitin_ligase_N8_Orf10_complex: Cul2_ubiquitin_ligase_N8_Orf10_substrate_Ub_complex
$Cul2_ubiquitin_ligase_N8_Orf10_substrate_complex: ((Cul2_ubiquitin_ligase_N8_Orf10_0E2_substrate_complex | Cul2_ubiquitin_ligase_N8_Orf10_E2_Ub_substrate_complex) | (Cul2_ubiquitin_ligase_Orf10_substrate_complex & UBE2M_NEDD8_complex))
$Cul2_ubiquitin_ligase_N8_complex: Cul2_ubiquitin_ligase_N8_substrate_Ub_complex
$Cul2_ubiquitin_ligase_N8_substrate_Ub_complex: Cul2_ubiquitin_ligase_N8_E2_substrate_Ub_complex
$Cul2_ubiquitin_ligase_Orf10_complex: ((Cul2_ubiquitin_ligase_Orf10_substrate_complex | (Cul2_ubiquitin_ligase_N8_Orf10_complex & CSN5_complex)) | (Cul2_ubiquitin_ligase_complex & Orf10))
$Cul2_ubiquitin_ligase_Orf10_substrate_complex: (Cul2_ubiquitin_ligase_Orf10_complex & sa105_ubit_traget_cytosol)
$Cul2_ubiquitin_ligase_complex: (((csa4_Cul2_ubiquitin_ligase_substrate_complex_cytosol | Cul2_ubiquitin_ligase_Orf10_complex) | (Cul2_ubiquitin_ligase_N8_complex & CSN5_complex)) | (Zyg11B_EloBC_complex & Rbx1_Cul2_complex))
$DUB: DUB_rna
$E1: ((E2 & E1_ubiquitinated) | E1_rna)
$E1_ubiquitinated: ((E1 & Ub_simple_molecule) & ATP_simple_molecule)
$E2: (((E2_rna | Cul2_ubiquitin_ligase_N8_E2_substrate_Ub_complex) | Cul2_ubiquitin_ligase_N8_E2_substrate_complex) | Cul2_ubiquitin_ligase_N8_Orf10_0E2_substrate_complex)
$E2_ubiquitinated: (((E2 & E1_ubiquitinated) | Cul2_ubiquitin_ligase_N8_E2_Ub_substrate_complex) | Cul2_ubiquitin_ligase_N8_Orf10_E2_Ub_substrate_complex)
$ELOB_ELOC_complex: ((((Zyg11B_EloBC_complex | ELOB_rna) | ELOB_ELOC_complex) | ELOC_rna) | ELOB_ELOC_complex)
$NAE_Pevonedistat_complex: (NAE_complex & Pevonedistat_drug)
$NAE_complex: ((((NAE_Pevonedistat_complex | NAE1_rna) | NAE_complex) | UBA3_rna) | NAE_complex)
$NEDD8: NEDD8_rna
$Orf10: (Orf10____ss_sgmRNA_rna | Cul2_ubiquitin_ligase_Orf10_complex)
$PPi_simple_molecule: ((E1 & Ub_simple_molecule) & ATP_simple_molecule)
$Pevonedistat_drug: NAE_Pevonedistat_complex
$Rbx1_Cul2_complex: ((((Cul2_ubiquitin_ligase_complex | RBX1_rna) | Rbx1_Cul2_complex) | CUL2_rna) | Rbx1_Cul2_complex)
$UBE2M_NEDD8_complex: ((((NEDD8 & NAE_complex) | UBE2M_rna) | (UBE2M_NEDD8_complex & csa4_Cul2_ubiquitin_ligase_substrate_complex_cytosol)) | (Cul2_ubiquitin_ligase_Orf10_substrate_complex & UBE2M_NEDD8_complex))
$ZYG11B: (ZYG11B_rna | Zyg11B_EloBC_complex)
$Zyg11B_EloBC_complex: (Cul2_ubiquitin_ligase_complex | (ELOB_ELOC_complex & ZYG11B))
$csa15_Cul2_ubiquitin_ligase_substrate_complex_cytosol: ((Cul2_ubiquitin_ligase_N8_E2_substrate_complex | Cul2_ubiquitin_ligase_N8_E2_Ub_substrate_complex) | (UBE2M_NEDD8_complex & csa4_Cul2_ubiquitin_ligase_substrate_complex_cytosol))
$csa4_Cul2_ubiquitin_ligase_substrate_complex_cytosol: (sa105_ubit_traget_cytosol & Cul2_ubiquitin_ligase_complex)
$sa105_ubit_traget_cytosol: (csa4_Cul2_ubiquitin_ligase_substrate_complex_cytosol | Cul2_ubiquitin_ligase_Orf10_substrate_complex)
$sa171_ubit_traget_cytosol: (ubit_traget_ubiquitinated & DUB)
$ubit_traget_ubiquitinated: (Cul2_ubiquitin_ligase_N8_substrate_Ub_complex | Cul2_ubiquitin_ligase_N8_Orf10_substrate_Ub_complex)